药物代谢酶的表观遗传调控机制研究进展

杨子钊,于琴琴,余露山,孙红颖,曾苏

中国药学杂志 ›› 2013, Vol. 48 ›› Issue (17) : 1425-1428.

中国药学杂志 ›› 2013, Vol. 48 ›› Issue (17) : 1425-1428. DOI: 10.11669/cpj.2013.17.001
综述

药物代谢酶的表观遗传调控机制研究进展

  • 杨子钊,于琴琴,余露山,孙红颖,曾苏
作者信息 +

Development of Research on Regulation Mechanism of Epigenetic Modifications for Drug Metabolic Enzymes

  • YANG Zi-zhao,YU Qin-qin,YU Lu-shan,SUN Hong-ying,ZENG Su
Author information +
文章历史 +

摘要

目的对当前表观遗传修饰(如DNA甲基化、组蛋白修饰,染色质重塑、非编码RNA干预等)调控下药物代谢酶基因表达与底物代谢异常的相关研究进行综述。方法笔者综述近年来药物代谢酶表观遗传修饰与催化底物代谢水平调控的研究进展。结果与结论为临床治疗确定生物标志物,并为肿瘤等疾病的治疗提供参考依据。

Abstract

OBJECTIVE To make a review of nowadays related dissertations about epigenetic modifications (DNA methylation,histone modifications,chromatin remodeling and the non-coding microRNA interruption,etc.) mediating the abnormal expression of drug metabolic enzymes and inactive metabolism of substances in organisms. METHODS Researches on epigenetic modifications regulating the genes expression or activity change of drug metabolism enzymes were reviewed. RESULTS AND CONCLUSION The research in this field can provide reference for determining biomarkers in clinical diagnosis and therapies of tumors.

关键词

药物代谢酶 / 表观遗传修饰 / 底物代谢 / 疾病预防

Key words

drug metabolism enzyme / epigenetic modification / substrate metabolism / disease prevention

引用本文

导出引用
杨子钊,于琴琴,余露山,孙红颖,曾苏. 药物代谢酶的表观遗传调控机制研究进展[J]. 中国药学杂志, 2013, 48(17): 1425-1428 https://doi.org/10.11669/cpj.2013.17.001
YANG Zi-zhao,YU Qin-qin,YU Lu-shan,SUN Hong-ying,ZENG Su. Development of Research on Regulation Mechanism of Epigenetic Modifications for Drug Metabolic Enzymes[J]. Chinese Pharmaceutical Journal, 2013, 48(17): 1425-1428 https://doi.org/10.11669/cpj.2013.17.001
中图分类号: R917   

参考文献

[1] FUKUSHIGE S,HORII A.DNA methylation in cancer: A gene silencing mechanism and the clinical potential of its biomarkers.Tohoku J Exp Med,2013,229(3):173-185.

[2] PARPART S,WANG X W.MicroRNA regulation and its consequences in cancer.Curr Pathobiol Rep,2013,1(1):71-79.

[3] CROW M,DENK F,MCMAHON S B.Genes and epigenetic processes as prospective pain targets.Genome Med.2013,5(2):12.

[4] JAMES L I,FRYE S V.Targeting chromatin readers.Clin Pharmacol Ther,2013,93(4):312-314.

[5] SCHNEIDER E,CLARK D S.Cytochrome P450 (CYP) enzymes and the development of CYP biosensors.Biosens Bioelectron.2013,39(1):1-13.

[6] ZANGER U M,SCHWAB M.Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression,enzyme activities,and impact of genetic variation.Pharmacol Ther, 2013,16: 103-141.

[7] MEECH R,MINERS J O,LEWIS B C,et al.The glycosidation of xenobiotics and endogenous compounds: Versatility and redundancy in the UDP glycosyltransferase superfamily.Pharmacol Ther,2012,134(2):200-218.

[8] BARBIER O,BLANGER A.Inactivation of androgens by UDP-glucuronosyltransferases in the human prostate.Best Pract Res Clin Endocrinol Metab,2008,22(2):259-270.

[9] MORRIS M,LIU D,WEAVER L M,et al.A structural basis for cellular uptake of GST-Fold proteins.PLos One,2011,6(3):17864.

DIDOVYK A,VERDINE G L.Structural origins of DNA target selection and nucleobase extrusion by a DNA cytosine methyltransferase.J Biol Chem,2012,287(48):40099-40105.

XIE S,CHEN Y,CHEN S,et al.Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9.J Pharm Pharmacol,2011,63(2):297-304.

BABA Y,WATANABE M,BABA H.A review of the alterations in DNA methylation in esophageal squamous cell carcinoma.Surg Today,2013,5:doi.10.1007S00595-012-0451-4.

VASANTHAKUMAR A,LEPORE J B,ZEGAREK M H,et al.Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.Blood, 2013,121(11):2059-2063.

HABANO W,GAMO T,SUGAI T,et al.CYP1B1,but not CYP1A1,is downregulated by promoter methylation in colorectal cancers.Int J Oncol,2009,34(4):1085-1091.

JOANNA F,VAN GRUNSVEN L A,MATHIEU V,et al.Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology.J Cell Mol Med,2009,13(9B):2990-3005.

PHAM T X,L J.Dietary regulation of histone acetylases and deacetylases for the prevention of metabolic diseases.Nutrients,2012,28;4(12):1868-1886.

LEE S H,KIM I J,KIM J G,et al.Regulation of intestinal stem cell proliferation by human methyl-CpG-binding protein-2 in Drosophila.Cell Struct Funct,2011,36(2):197-208.

TANG Y,URS S,LIAW L.Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site.Circ Res,2008,102(6):661-668.

HREBACKOVA J,HRABETA J,ECKSCHLAGER T.Valproic acid in the complex therapy of malignant tumors.Curr Drug Targets,2010,11(3):361-379.

WU Y,SHI X,LIU Y,et al.Histone deacetylase 1 is required for carbamazepine-induced CYP3A4 expression.J Pharm Biomed Anal,2012,58:78-82.

TIGGES J,WEIGHARDT H,WOLFF S,et al.Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression.J Invest Dermatol,2013,133(1):87-96

DE LIMA J C,LOSS-MORAIS G,MARGIS R.MicroRNAs play critical roles during plant development and in response to abiotic stresses.Genet Mol Biol, 2012,35(4 suppl):1069-1077.

RANJHA R,PAUL J.Micro-RNAs in inflammatory diseases and as a link between inflammation and cancer.Inflamm Res,2013,62(4):343-355.

CARROLL A P,TOONEY P A,CAIRNS M J.Context-specific microRNA function in developmental complexity.J Mol Cell Biol,2013,5(2):73-84.

VELU V K,RAMESH R,SRINIVASAN A R.Circulating microRNAs as biomarkers in health and disease.J Clin Diagn Res,2012,6(10):1791-1795.

AMERES S L,HORWICH M D,HUNG J H,et al.Target RNA-directed trimming and tailing of small silencing RNAs.Science,2010,328(5985):1534-1539.

KALSCHEUER S,ZHANG X,ZENG Y,et al.Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.Carcinogenesis,2008,29(12):2394-2399.

WANG Y,HU H H,PANG H,et al.Lentiviral transgenic microRNA-based shRNA suppressed mouse cytochromosome P450 3A (CYP3A) expression in a dose-dependent and inheritable manner.PLoS One,2012,7(1):30560.

HUANG F F,CHAI C L,ZHANG Z,et al.The UDP-glucosyltransferase multigene family in Bombyx mori.BMC Genomics.November,2008,9:563.

BOCK K W,BOCK-HENNIG B S.UDP-glucuronosyltransferases (UGTs): From purification of Ah-receptor-inducible UGT1A6 to coordinate regulation of subsets of CYPs,UGTs,and ABC transporters by nuclear receptors.Drug Metab Rev,2010,42(1):6-13.

BOCK KW,KHLE C.Topological aspects of oligomeric UDP-glucuronosyltransferases in endoplasmic reticulum membranes: advances and open questions.Biochem Pharmacol,2009,77(9):1458-1465.

BAJRO M H,JOSIFOVSKI T,PANOVSKI M,et al.Promoter length polymorphism in UGT1A1 and the risk of sporadic colorectal cancer.Cancer Genet,2012,205(4):163-167.

FUJITA K,ANDO Y,YAMAMOTO W,et al.Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer.Cancer Chemother Pharmacol,2010,65(2):251-258.

GAGNON J F,BERNARD O,VILLENEUVE L,et al.Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer.Clin Cancer Res,2006,12(6):1850-1858.

ODA S,FUKAMI T,YOKOI T,et al.Epigenetic regulation is a crucial factor in the repression of UGT1A1 expression in the human kidney.Drug Metab Dispos,2013,11.doi:10.1124/dmd.113051201.

BIN Q,LUO J.Role of polymorphisms of GSTM1,GSTT1 and GSTP1 Ile105Val in hodgkin and non-hodgkin iymphoma risk: A human genome epidemiology (HuGE) review.Leuk Lymphoma,2013,54(1):14-20.

KATOH T,YAMANO Y,TSUJI M,et al.Genetic polymorphisms of human cytosol glutathione S-transferases and prostate cancer.Pharmacogenomics,2008,9(1):93-104.

SAXENA A,DHILLON V S,SHAHID M,et al.GSTP1 methylation and polymorphism increase the risk of breast cancer and the effects of diet and lifestyle in breast cancer patients.Exp Ther Med,2012,4(6):1097-1103.

TANG S C,WU M F,WONG R H,et al.Epigenetic mechanisms for silencing glutathione S-transferase m2 expression by hypermethylated specificity protein 1 binding in lung cancer.Cancer,2011,117(14):3209-3221.

MAVIS C K,SHANNON R,MOREY K,et al.Expression leveland DNAMethylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors.Prostate, 2009,69(12):1312-1324.

基金

国家自然科学基金资助项目(81273579);高等学校博士学科点专项科研基金资助项目(20110101130015)

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